| ORIGINAL ARTICLE |
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| Year : 2008 | Volume
: 12
| Issue : 2 | Page : 41-44 |
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Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis
Neetha Shetty1, Biju Thomas2, Amita Ramesh2
1 Department of Periodontics, MCODS, Mangalore., India
2 Department of Periodontics, ABSMIDS, Mangalore, India
Correspondence Address:
Neetha Shetty
Department of Periodontics, MCODS, Mangalore - 575 001.
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-124X.44089
Clinical trial registration None
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Background : Diabetes mellitus is a systemic condition that has long been associated with an increased risk and severity of periodontal disease. Polymorphonuclear leukocytes (PMNs) play a key role in the maintenance of gingival and periodontal health. Reduced PMN function has been found in patients with diabetes. Aim: The objective of this study was to evaluate PMN functions in 15 diabetic patients with chronic generalized periodontitis. Materials and Methods: Chemotaxis, superoxide production, phagocytosis and killing of Porphyromonas gingivalis by diabetic PMNs were evaluated relative to healthy and matched controls. Results: These analyses revealed a significant (P < 0.01) depression in the number of diabetic PMNs migrating along an fMLP gradient. In addition, a significant (P < 0.01) enhancement of diabetic PMN superoxide production was observed. Phagocytosis (P < 0.05) and killing by diabetic PMN of P. gingivalis was also impaired significantly (P < 0.01). |
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