Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
Home | About JISP | Search | Accepted articles | Online Early | Current Issue | Archives | Instructions | SubmissionSubscribeLogin 
Users Online: 868  Home Print this page Email this page Small font size Default font size Increase font sizeWide layoutNarrow layoutFull screen layout


 
   Table of Contents    
CASE REPORT
Year : 2013  |  Volume : 17  |  Issue : 2  |  Page : 239-241  

Intramucosal melanotic nevi - A case report of an unusual gingival enlargement


Department of Periodontology and Implantology, Dental College, Azamgarh, Uttar Pradesh, India

Date of Submission22-Dec-2010
Date of Acceptance17-Aug-2012
Date of Web Publication6-Jun-2013

Correspondence Address:
Jyoti Agrawal
Kashi Dental Hospital, P-3/10, Lane Number 17, Ravindrapuri Colony, Varanasi - 221 005, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-124X.113087

Rights and Permissions
   Abstract 

Intramucosal melanotic nevus with multiple polypoid presentations in oral cavity is rare; though single nevus is not uncommon. Nevi are benign proliferations of nevus cells either in the epithelium or in the subepithelial stroma. They are best categorized as hamartomas rather than true neoplasm. We present a case of intramucosal melanotic nevi in a 26-year-old male patient, which clinically resembled hereditary fibrous gingival enlargement.

Keywords: Melanoma, nevi, polypoid intramucosal, theque


How to cite this article:
Agrawal J. Intramucosal melanotic nevi - A case report of an unusual gingival enlargement. J Indian Soc Periodontol 2013;17:239-41

How to cite this URL:
Agrawal J. Intramucosal melanotic nevi - A case report of an unusual gingival enlargement. J Indian Soc Periodontol [serial online] 2013 [cited 2021 Apr 16];17:239-41. Available from: https://www.jisponline.com/text.asp?2013/17/2/239/113087


   Introduction Top


Intramucosal melanotic nevi with multiple polypoid presentation in oral cavity are rare though solitary nevi are not uncommon. [1]

In 1943, Ackermann and Field have reported the first documented case of an oral Nevus. [2]

Comerford et al., were the first to propose the term Intralamina propia Nevus. [3] King et al., 1967 adopted the less anatomically specific term, Intramucosal nevus which clinician understand easily. [4]

White adults have ten to forty cutaneous nevi on an average, but intraoral lesions are rare. Nevi are classified as acquired or congenital. Oral nevi follow the same classification as that of cutaneous nevi however; the term intradermal is replaced by intramucosal.

Pathophysiology

Although little doubt exist that nevus cells arise from the neural crest, whether the cells represent true melanocytes or are closely related. Distinct cell type is debatable. Melanocytes are located suprabasally in the epithelium, are dendritic cells and transfer melanin to the adjacent keratinocytes. On the contrary nevus cell has rounded cytoplasm and lack the dendritic processes, typical of melanocytes. Normally melanin is retained by nevus cells and not transferred to adjacent keratinocytes.

The intramucosal nevus is composed of a bulk of nevus cells in the mucosal epithelium. Approximately 15% of intramucosal nevi are non-pigmented. Melanotic nevi can be present at birth, or they may appear shortly after birth.


   Case Report Top


A 26-year-old male presented at the outpatient department with the chief complaint of irritation from lower anterior teeth and a mass present on upper front region of jaw [Figure 1]. Tumor was present since birth, was red in color initially and it gradually increased to its present size.
Figure 1: Preoperative view before extraction

Click here to view


Patient sustained an accident one year back, which caused loss of right, lateral incisor and following accident the color of the mass changed to black. Lesion was asymptomatic otherwise.

Clinical examination revealed an indurate, black nodular lesion of about 8-10 cm in diameter, firm in consistency and rough textured with irregular margins.

Periodontal probe was used to detect any false or true pocket but there was no evidence of periodontal disease. Radiographically, neither the bone loss nor any sign of radiolucency was present. Preoperative clinical diagnosis was fibrous enlargement vis-à-vis to melanoma. Patient was advised extraction of right central incisor [Figure 2] and [Figure 3] (In consultation with department of prosthodontic to rule out its interference with fixed prosthesis fabrication.)
Figure 2: Preoperative facial view after extraction

Click here to view
Figure 3: Preoperative palatal view

Click here to view


Treatment

Incision biopsy was performed. Following histological report of nevus, gingivectomy was undertaken with adequate alveoloplasty [Figure 4] and [Figure 5]. Healing was satisfactory after one month [Figure 6].
Figure 4: Intra operative view (after gingivectomy)

Click here to view
Figure 5: Excised tissue

Click here to view
Figure 6: Post operative view (after one month)

Click here to view


Histological findings

H and E section revealed parakeratinized stratified squamous epithelium. Pigmented nevus cells were seen in circumscribed groups (theques) in the connective tissue subjacent to the epithelium. Chronic inflammatory cells were also present around the theques. A diagnosis of Intramucosal Melanotic Nevi was offered [Figure 7] and [Figure 8].
Figure 7: Histopathologic view (H and E ×100)

Click here to view
Figure 8: Histopathologic view (H and E ×400)

Click here to view


The patient remained uneventful almost one year following operation till date and is advised follow up.


   Discussion Top


Nevi are benign lesion, present commonly on the skin but also occur in oral mucosa. They may present as round or oval well circumscribed; slightly raised in 65-80% cases. Oral nevi are usually smooth and rarely have a papillated or rough surface. In present case Nevi was neither well circumscribed nor round and smooth but had irregular margins and was multi polypoid in nature. The Intramucosal type of oral nevus is most common by far and represents 63 [5] to 70% [6] of all oral nevi, most common on the hard palate (40%). Second most common location is the buccal mucosa (20%), 10% of all types of oral nevi are found on gingiva. Among all nevi approximately 17% of intramucosal nevi are on the gingiva. [7] The present case of intramucosal nevi was on gingival surface, a rare finding. About 75% of the nevi smaller than 0.6 cm. Nevi larger than 1.3 cm were present in only about 5% of the cases. The present case is unique with an exceptional large size of 8-10 cm. In general, the larger nevi are considered to be congenital akin to the present case. [8]


   Conclusion Top


Although congenital nevi in the oral cavity have been reported, they are extremely rare, none underwent malignant transformation. Further gingival surface nevi, an exceptional giant size is unique to the present case.

 
   References Top

1.Cawson RA, Binnie WH, Speight PM, Barrett AW. Oral Nevi. Lucas Pathology of Tumors of the oral tissues, 5 th ed, London: Churchill Livingstone; 1998. p. 328.  Back to cited text no. 1
    
2.Elder DE, Greene MH, Bondi EE, Clark WH Jr. Acquired melanotic nevi and Melanoma: The dysplastic nevus syndrome. In: Ackerman AB, editor. Pathology of Malignant Melanoma. New York: Masson Publishing; 1981. p. 185-215.  Back to cited text no. 2
    
3.Comerford TE, Jr Delapava S, Pickren JW. Nevus of the oral cavity. Oral Surg Oral Med Oral Pathol 1964;17:148-51.  Back to cited text no. 3
    
4.King OH Jr, Blankenship JP, King WA, Coleman SA. The frequency of pigmented nevi in the oral cavity. Report of five cases. Oral Surg Oral Med Oral Pathol 1967;23:82-90.  Back to cited text no. 4
    
5.Buchner A, Lieder AS, Merrell PW, Carpenter WM. Melanotic nevi of the oral mucosa: A clinicopathologic study of 130 cases from northern California. J Oral Pathol Med 1990;19:197-201.  Back to cited text no. 5
    
6.Watkins KV, Chaudhary AP, Yamane GM. Benign focal melanotic lesion of oral mucosa. J Oral Med 1984;39:91-6.  Back to cited text no. 6
    
7.Buchner A, Hansen LS. Pigmented nevi of the oral mucosa: A clinico pathologic study of 32 new cases and review of 75 cases from the literature. Part II. Analysis of 107 cases. Oral Surg Oral Med Oral Patho 1980;49:55-62.  Back to cited text no. 7
    
8.Buchner A, Merrell PW, Carpenter WM. Relative frequency of solitary melanocytes lesions of the oral mucosa. J Oral Pathol Med 2004;33:550-7.  Back to cited text no. 8
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8]



 

Top
   
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed2011    
    Printed35    
    Emailed0    
    PDF Downloaded168    
    Comments [Add]    

Recommend this journal