| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 18
| Issue : 6 | Page : 728-733 |
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Assessment of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in Down's syndrome subjects and systemically healthy subjects: A comparative clinical trial
Nizar Ahmed1, Harinath Parthasarathy2, Mohamed Arshad1, Dhayanand John Victor1, Danny Mathew1, Siva Sankari1
1 Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, India
2 Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India
Correspondence Address:
Nizar Ahmed
Thai Moogambigai Dental College Golden George Nagar Mugapair, Chennai - 600 107, Tamilnadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-124X.147408
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Objectives: To compare and quantify the presence of periodontal pathogens Aggregatibacter actinomycetemcomitans (Aac) and Porphyromonas gingivalis (Pg) in Down's syndrome (DS) and systemically healthy subjects with periodontitis and gingivitis. Materials and Methods: Fifty‑nine age‑matched subjects
were categorized into four groups; Group I: DS subjects with gingivitis, Group II: DS subjects with periodontitis, Group III: Systemically healthy subjects with gingivitis and Group IV: Systemically healthy subjects with periodontitis.
Plaque samples from all the four groups were collected and analyzed to evaluate the presence of Aac and Pg using real time polymerase chain reaction. The indices used were oral hygiene index simplified, community periodontal
index for treatment needs and plaque index. Results: This study showed a statistically significant detection in
the levels of both Aac (<0.001) and Pg (<0.001) in DS subjects with periodontitis when compared with the healthy
controls with periodontitis; moreover, there was a statistically significant increase in Pg levels compared to Aac in
DS gingivitis group. Conclusion: There was a statistically significant presence of Pg and Aac in both DS gingivitis
and DS periodontitis over control groups with increased levels of Pg compared with Aac in DS gingivitis group. |
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