Journal of Indian Society of Periodontology
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LETTER TO EDITOR
Year : 2015  |  Volume : 19  |  Issue : 2  |  Page : 129  

Salivary tumor necrosis factor-α and periodontal destruction


1 Medical Center, Shantou, China
2 Hainan Medical University, Haikou, China

Date of Web Publication23-Apr-2015

Correspondence Address:
Prof. Sim Sai Tin
Medical Centre, Shantou
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-124X.155713

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How to cite this article:
Tin SS, Wiwanitkit V. Salivary tumor necrosis factor-α and periodontal destruction. J Indian Soc Periodontol 2015;19:129

How to cite this URL:
Tin SS, Wiwanitkit V. Salivary tumor necrosis factor-α and periodontal destruction. J Indian Soc Periodontol [serial online] 2015 [cited 2021 Aug 3];19:129. Available from: https://www.jisponline.com/text.asp?2015/19/2/129/155713

Sir,

Singh et al. reported an observation on "salivary tumor necrosis factor-α (TNF-α) and periodontal destruction. [1]" Singh et al. concluded "diabetes status increased TNF-α significantly in comparison to smoking in chronic periodontitis patients. [1]" In the present report the consideration is on the confounding factors, such as other concomitant pathology or risks (such as smoking), which might affect salivary TNF-α. In a previous report by Yousefimanesh et al., it was reported "this biomarker cannot seem to be a good index to evaluate or predict periodontal disease. [2]" In addition, it is also questionable about the diagnostic property of the salivary TNF-α for differentiate of severity of destruction. Finally, it will be more useful if a comparative study with other markers (such as salivary cotinine [3] or immunoglobulin [4] ) to compare efficacy and cost-effectiveness.

 
   References Top

1.
Singh P, Gupta ND, Bey A, Khan S. Salivary TNF-alpha: A potential marker of periodontal destruction. J Indian Soc Periodontol 2014;18:306-10.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Yousefimanesh H, Maryam R, Mahmoud J, Mehri GB, Mohsen T. Evaluation of salivary tumor necrosis factor-alpha in patients with the chronic periodontitis: A case-control study. J Indian Soc Periodontol 2013;17:737-40.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.
Surya C, Swamy DN, Chakrapani S, Kumar SS. Chairside quantitative immunochromatographic evaluation of salivary cotinine and its correlation with chronic periodontitis. J Indian Soc Periodontol 2012;16:508-12.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.
Awartani F. Serum immunoglobulin levels in type 2 diabetes patients with chronic periodontitis. J Contemp Dent Pract 2010;11:001-8.  Back to cited text no. 4
    




 

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