Journal of Indian Society of Periodontology
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   Table of Contents    
AUTHORíS REPLY
Year : 2015  |  Volume : 19  |  Issue : 2  |  Page : 129-130  

Author's reply: Salivary tumor necrosis factor-alpha: The way ahead


Department of Periodontics, Dr. Ziauddin Ahmad Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Date of Web Publication23-Apr-2015

Correspondence Address:
Dr. Pritma Singh
C/O Vinod Aggrawal, Near Kalyan Singh Kothi, Marris Road, Aligarh, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-124X.155714

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How to cite this article:
Singh P, gupta ND, Bey A, Khan S. Author's reply: Salivary tumor necrosis factor-alpha: The way ahead. J Indian Soc Periodontol 2015;19:129-30

How to cite this URL:
Singh P, gupta ND, Bey A, Khan S. Author's reply: Salivary tumor necrosis factor-alpha: The way ahead. J Indian Soc Periodontol [serial online] 2015 [cited 2021 Aug 3];19:129-30. Available from: https://www.jisponline.com/text.asp?2015/19/2/129/155714

Sir,

In the study of Singh et al., [1] salivary tumor necrosis factor-alpha (TNF-alpha) showed significant variation among the groups and co-related with the systemic and smoking status, which are, although not in the ambit of the study of Singh et al., known to result greater periodontal tissue destruction. [2],[3] This inference suggested TNF-alpha as a marker of severity of periodontal destruction. Furthermore, Singh et al. underlined the respective influence of both the confounders upon Salivary TNF-alpha levels suggesting a role of TNF-alpha in pathogenic influence of these conditions upon existing periodontitis.

Ultimate use of salivary TNF-alpha as biomarker would require not only the baseline salivary TNF-alpha levels across racially varied populations, but also an estimation of the influence of these socially prevalent confounders. It will also be useful to establish an independent influence of systemic confounders like diabetics and to smoke on salivary TNF-alpha to understand undiluted role of these conditions in periodontitis subjects in both health and disease.


   Acknowledgement Top


We acknowledge the effort of Dr. Shagufta, Department of Biochemistry, JNMC for her assistance in sample testing and laboratory provisions.

 
   References Top

1.
Singh P, Gupta ND, Bey A, Khan S. Salivary TNF-alpha: A potential marker of periodontal destruction. J Indian Soc Periodontol 2014;18:306-10.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Bergström J. Tobacco smoking and chronic destructive periodontal disease. Odontology 2004;92:1-8.  Back to cited text no. 2
    
3.
Bascones-Martínez A, Arias-Herrera S, Criado-Cámara E, Bascones-Ilundáin J, Bascones-Ilundáin C. Periodontal disease and diabetes. Adv Exp Med Biol 2012;771:76-87.  Back to cited text no. 3
    




 

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