Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2015  |  Volume : 19  |  Issue : 2  |  Page : 131-141

Interleukin polymorphisms in aggressive periodontitis: A literature review

Department of Periodontics, Louisiana State University Health Sciences Center, School of Dentistry, New Orleans, Louisiana, USA

Correspondence Address:
Dr. Pooja Maney
Room No. 5443, 1100 Florida Avenue, New Orleans, Louisiana - 70002
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Source of Support: LSUHSC School of Dentistry, Department of Periodontics, Conflict of Interest: None

DOI: 10.4103/0972-124X.145787

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Aggressive periodontitis (AgP), occurs in a younger age group (≤35 years) and is associated with the rapid destruction of periodontal attachment and supporting bone. Genetic polymorphisms are allelic variants that occur in at least 1% of the population that could potentially alter the function of the proteins that they encode. Interleukins are a group of cytokines that have complex immunological functions including proliferation, migration, growth and differentiation of cells and play a key role in the immunopathogenesis of periodontal disease. The aim of this review was to summarize the findings of studies that reported associations or potential associations of polymorphisms in the interleukin family of cytokines, specifically with AgP.

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