Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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REVIEW ARTICLE
Year : 2015  |  Volume : 19  |  Issue : 2  |  Page : 142-149

The epigenetic paradigm in periodontitis pathogenesis


1 Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
2 Department of Human Genetics, Faculty of Bio-Medical Sciences, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India

Correspondence Address:
Prof. Suresh Ranga Rao
Department of Periodontology and Implantology, Faculty of Dental Sciences, Sri Ramachandra University, No. 1, Ramachandra Nagar, Porur, Chennai - 600 116, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-124X.145784

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Epigenome refers to "epi" meaning outside the "genome." Epigenetics is the field of study of the epigenome. Epigenetic modifications include changes in the promoter CpG Islands, modifications of histone protein structure, posttranslational repression by micro-RNA which contributes to the alteration of gene expression. Epigenetics provides an understanding of the role of gene-environment interactions on disease phenotype especially in complex multifactorial diseases. Periodontitis is a chronic inflammatory disorder that affects the supporting structures of the tooth. The role of the genome (in terms of genetic polymorphisms) in periodontitis pathogenesis has been examined in numerous studies, and chronic periodontitis has been established as a polygenic disorder. The potential role of epigenetic modifications in the various facets of pathogenesis of periodontitis is discussed in this paper based on the available literature.


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