Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2015  |  Volume : 19  |  Issue : 2  |  Page : 182-187

A randomised clinical study to measure the anti-erosion benefits of a stannous-containing sodium fluoride dentifrice

1 Department of Oral and Dental Sciences, University of Bristol Dental School and Hospital, Bristol, United Kingdom
2 Procter and Gamble Company, Mason, OH, USA

Correspondence Address:
Prof. Nicola West
Department of Oral and Dental Sciences, University of Bristol Dental School and Hospital, Bristol
United Kingdom
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Source of Support: The study was supported by the Procter and Gamble Company, Conflict of Interest: Drs. He and Barker are employees of the Procter and Gamble Company.

DOI: 10.4103/0972-124X.145817

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Background: To compare the enamel protection efficacy of stannous-containing sodium fluoride and sodium monofluorophosphate (MFP)/triclosan dentifrices marketed in India in an in situ erosion model with acidic challenge. Materials and Methods: This randomised and controlled, in situ, supervised, double-blind clinical trial employed a two-treatment, four-period crossover design, wherein subjects wore an appliance fitted with human enamel samples 6 h/day during each 10 day treatment period and swished twice daily with their assigned dentifrice slurry: Oral-B ® Pro-Health (maximum 1,000 ppm F as sodium fluoride with stannous chloride) or Colgate ® Strong Teeth with Cavity Protection (maximum 1,000 F as sodium MFP and triclosan). Subjects swished with 250 ml of orange juice over a 10 min period after each treatment and twice daily for the acidic erosive challenge. Enamel samples were measured for tooth surface loss using contact profilometry at baseline and day 10. Results: A total of 34 subjects were randomised to treatment; 32 subjects completed the final visit. Baseline profilometry measurements of the specimen surfaces were near zero within ± 0.3 μm, and no statistically significant difference (P > 0.48) on average was observed between the two test dentifrices. At day 10, the stannous-containing dentifrice demonstrated 88% less erosion (P < 0.0001) relative to the MFP/triclosan dentifrice. Estimated medians (95% confidence intervals) were 0.21 μm (0.17, 0.25) for the stannous-containing dentifrice versus 1.66 μm (1.39, 1.99) for the MFP/triclosan dentifrice. Both dentifrices were well-tolerated. Conclusions: Compared with MFP/triclosan toothpaste, a stabilised stannous-containing sodium fluoride dentifrice gave statistically significantly greater protection against tooth enamel surface loss in situ following repeated acid erosive challenge.

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