Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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REVIEW ARTICLE
Year : 2017  |  Volume : 21  |  Issue : 3  |  Page : 180-185

Neutrophil priming: Implications in periodontal disease


Department of Periodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India

Correspondence Address:
Rucha Shah
Room No 5, Department of Periodontics, Bapuji Dental College and Hospital, Davangere - 577 004, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jisp.jisp_385_15

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Periodontal disease is a well-regulated response to bacterial infection directed by the inflammatory cells of the host immune system. The host response to injury or insult is implicated to be a vital feature of the majority of periodontal diseases. The excessive activation of neutrophils plays a role in the pathogenesis in diseases such as acute respiratory distress syndrome, rheumatoid arthritis, and periodontitis by contributing to inflammatory tissue injury. In the recent times, there has been a shift of paradigm from a hypo- to hyper-responsive/primed model of neutrophil dysfunction in periodontal etiopathogenesis. The aim of this review is to outline the mechanisms and effects of neutrophil priming, and thereafter, discuss the current controversy that exists regarding the role of primed neutrophils in periodontal etiopathogenesis.


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