Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
Home | About JISP | Search | Accepted articles | Online Early | Current Issue | Archives | Instructions | SubmissionSubscribeLogin 
Users Online: 165  Home Print this page Email this page Small font size Default font size Increase font sizeWide layoutNarrow layoutFull screen layout
Year : 2017  |  Volume : 21  |  Issue : 6  |  Page : 494-498

Association of human leukocyte antigens Class I and Class II antigens with chronic periodontitis in East India

1 Department of Periodontology, Haldia Institue of Dental Science and Research, Haldia, West Bengal, India
2 Department of Periodontology, Rishi Raj College of Dental Sciences, Bhopal, Madhya Pradesh, India
3 Department of Periodontology, Dr R Ahmed Dental College and Hospital, Kolkata, West Bengal, India
4 Department of Periodontology, Buddha Institute of Dental Science and Post Graduate Institute, Patna, Bihar, India

Correspondence Address:
Neeraj Agrawal
Department of Periodontology, Rishi Raj College of Dental Sciences, Bhopal - 462 037, Madhya Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisp.jisp_309_16

Rights and Permissions

Context: Human leukocyte antigens (HLAs) have an important role in the determination of susceptibility and resistance to periodontal diseases in humans, which may vary from population to population. Aims: The aim of this study was to find out the association of HLA Classes I and II genes with chronic periodontitis in East Indian population. Materials and Methods: In a cross-sectional study design, a total of sixty participants of chronic periodontitis (CP) (mean age: 44.12 ± 5.85) and sixty subjects of periodontal disease-free controls (NP) Periodontitis free controls (mean age 41.85 ± 7.71) were analyzed for their various HLA combinations using serologic (microlymphocytotoxicity test) method. The results are further compared with the HLA profile of 100 samples of blood donors for which periodontal status was unknown. All the data were statistically analyzed by applying Chi-square test, Results: HLA-B7 (P = 0.003), DR7 (P = 0.001), DR53 (P = 0.001), and DQ3 (P = 0.001) were identified as susceptible phenotypes to CP, whereas HLA-A1 (P = 0.010), A3 (P = 0.001), and Cw4 (P = 0.001) phenotypes were identified to be associated with disease resistance. Conclusion: The HLA-B7, DR7, DR53, and DQ3 alleles may represent as risk factors for CP in Eastern Population of India, whereas HLA-A1, A3, and Cw4 may indicate to protective factors for CP of the same.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded98    
    Comments [Add]    

Recommend this journal