Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2019  |  Volume : 23  |  Issue : 5  |  Page : 424-429

Higher interleukin-33 levels in aggressive periodontitis cases

1 Department of Periodontology, DSCDS; Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India
2 Department of Periodontology, Government Dental College and Research Institute; Department of Periodontology, The Oxford Dental College, Bengaluru, Karnataka, India
3 Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Sujatha Pai Ballambettu
B.#811, 10th Main Road, Jayanagar 4th Block, Bengaluru - 560 011, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisp.jisp_217_19

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Context: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection. Aims: This study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene. Settings and Design: This is a cross-sectional, biochemical, genetic study. Materials and Methods: Ninety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism. Results: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33. Conclusions: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.

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