Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2020  |  Volume : 24  |  Issue : 6  |  Page : 593-596

Galleria mellonella as an experimental model for studying periodontopathogens

Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, SP, Brazil

Correspondence Address:
Dr. Ana Lia Anbinder
Av Engenheiro Francisco Jose Longo, 777, Jardim Sao Dimas, Sao Jose dos Campos, SP
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisp.jisp_631_19

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In the present study, Galleria mellonella was evaluated as a potential infection model for periodontal bacteria, more specifically, Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. All the bacteria evaluated were pathogenic to G. mellonella, causing their death in a concentration-dependent manner, and a decrease in their hemocyte count. Moreover, it was possible to recover the bacteria from the larvae hemolymph and determine the colony-forming units per larvae. G. mellonella is an effective model that may help to better understand the host-microbe interactions in periodontics.

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