Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2021  |  Volume : 25  |  Issue : 4  |  Page : 278-282

Evidence revealing the role of T cell regulators (Tregs) in periodontal diseases: A review

1 Department of Periodontics, Priyadarshini Dental College and Hospital, Thiruvallur, India
2 Department of Pedodontics, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India
3 Department of Periodontics, Indira Gandhi Dental College and Hospital, Puducherry, India

Correspondence Address:
Paavai Ilango
Priyadarshini Dental College and Hospital, No. 1. V. G. R Gardens, V. G. R. Nagar, Pandur, Thiruvallur - 631 203, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisp.jisp_308_20

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Periodontitis is an inflammatory disease of the periodontium, which is a reflection of the overgrowth of oral commensals. This alteration in the oral microbiota initiates inflammation of the gingiva, which when left untreated, terminates with the resorption of the alveolar bone that may lead to a poor and hopeless prognosis. With upcoming trends in modulating the host's immunity, the role of regulatory T-cells has gained importance. These T-cells defend against inflammation and autoimmunity as they suppress both. However, in both the conditions, the regulatory cells are invariably reduced in number. Novel methods to enhance the function of Tregs have made their way in dentistry, as a promising approach to cure periodontitis. This article discusses various significant tests and trials of Tregs in the recent years.

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