Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Year : 2022  |  Volume : 26  |  Issue : 4  |  Page : 348-352

Matrix metalloproteinase-9-1562 C/T promoter gene polymorphism in chronic periodontitis: A cross-sectional observational study

1 Dental Department, North Bengal Medical College and Hospital, Siliguri, West Bengal, India
2 Department of Periodontics, CSI College of Dental Sciences and Research, Madurai, Tamil Nadu, India
3 Department of Periodontics, Burdwan Dental College and Hospital, Bardhaman, West Bengal, India
4 Department of Periodontics, Dr. R Ahmed Dental College and Hospital, West Bengal, India

Correspondence Address:
Thamil Selvan Muthuraj
29/4, C-1, O Trunk Road, Sattur, Viruthunager - 626 203, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisp.jisp_80_21

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Background: Matrix metalloproteinases (MMPs) are a major group of enzymes, released in inflamed periodontal tissues in large quantities, resulting in connective tissue matrix breakdown. One of the most predominant MMPs is MMP-9. Association between chronic periodontitis (CP) and MMP-9 gene polymorphism (GP) in some ethnic populations has been already established. The aim of the current study was to assess the association of single-nucleotide polymorphism in the promoter region of MMP-9 gene with CP in Kolkata population, if any. Materials and Methods: Forty eligible individuals were recruited for the study and grouped as A and B: Group A (twenty periodontally healthy individuals) and Group B (twenty CP patients). Venous blood samples collected from all the forty individuals were used to isolate the genomic DNA. GP for MMP-9 gene was detected using polymerase chain reaction and sequencing method. The data obtained were then analyzed statistically. Results: A significantly different genotypic and allelic variation was observed in the control and test groups, with C/T genotype and T allele present in only CP group. Conclusion: Within the limitations of this study, we can conclude that there was no significant association between patients with periodontitis and MMP-9-1562 C/T promoter GP.

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