Journal of Indian Society of Periodontology
Journal of Indian Society of Periodontology
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Gingival squamous cell carcinoma masquerading as necrotizing ulcerative periodontitis

1 Department of Periodontics, Dr. Ziauddin Ahmad Dental College, Aligarh, Uttar Pradesh, India
2 Department of Pathology, J N Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
3 Department of Dentistry, Palamu Medical College, Palamu, Jharkhand, India

Correspondence Address:
Saif Khan,
Department of Periodontics and Community Dentistry, Dr. Ziauddin Ahmad Dental College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisp.jisp_175_20

Necrotizing ulcerative periodontitis (NUP) is a painful and debilitating condition seen mostly in an immunocompromised state. Although squamous cell carcinoma (SCC) on gingiva is not uncommon, its presentation as a benign necrotizing lesion on gingiva is rare. Such presentations may lead to delayed diagnosis and poor prognosis. This report describes a case of a 34-year-old male presenting clinically with NUP around mandibular posterior teeth. Clinical features were misleading, but the histological findings established the diagnosis of well-differentiated SCC. Immunohistochemistry also showed features of epithelial–mesenchymal transition with decreased expression of E-cadherin and increased vimentin expression showing local invasion and metastasis. The patient was referred to the oncology department for evaluation of possible metastasis and further management of carcinoma.

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