Journal of Indian Society of Periodontology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 18  |  Issue : 2  |  Page : 187--193

Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis


DS Pushparani1, S Nirmala Anandan1, P Theagarayan2 
1 Department of Biochemistry, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India
2 Department of Periodontology and Oral Implantology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India

Correspondence Address:
D S Pushparani
Department of Biochemistry, SRM Dental College, Ramapuram, Chennai - 600 089, Tamil Nadu
India

Aim: The purpose of the study was to evaluate the serum levels of zinc (Zn) and magnesium (Mg) in type 2 diabetes mellitus (DM) with periodontitis patients and to correlate them with the levels of serum cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), and triglycerides among the study subjects. Materials and Methods: A total of 600 subjects participated in the study, who were divided into four groups as control healthy individuals (group I), type 2 DM without periodontitis (group II), type 2 DM with periodontitis (group III), and periodontitis subjects without DM (group IV), matched for age, sex, and duration of diabetes. Serum concentrations of glucose, total cholesterol, triglycerides, HDL-c, Zn, and Mg were measured using enzymatic methods in an UV absorption spectrophotometer, and LDL-c was calculated using Friedwald«SQ»s formula. Student«SQ»s t-test, Pearson correlations, and analysis of variance (ANOVA) tests were used for statistical analysis. Results: The serum zinc level was found to be significantly increased in type 2 DM without periodontitis (group II) and periodontitis subjects without type 2 DM (group IV) (P < 0.0001), and the level was lowered in type 2 DM with periodontitis (group III) when compared to control. The serum Mg level was found to be significantly decreased (P < 0.0001) in group II, group III, and in group IV, when compared to control. We found a significant increased level of serum total cholesterol and LDL-c and decreased triglycerides and HDL-c in type 2 DM subjects with periodontitis (group III, P < 0.0001). Conclusion: Patients with DM and periodontitis had altered metabolism of Zn and Mg which were linked to increased values of serum cholesterol and LDL-c and decreased HDL-c, contributing to the progression and complications of type 2 DM with periodontitis.


How to cite this article:
Pushparani D S, Anandan S N, Theagarayan P. Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis.J Indian Soc Periodontol 2014;18:187-193


How to cite this URL:
Pushparani D S, Anandan S N, Theagarayan P. Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis. J Indian Soc Periodontol [serial online] 2014 [cited 2021 Sep 22 ];18:187-193
Available from: https://www.jisponline.com/article.asp?issn=0972-124X;year=2014;volume=18;issue=2;spage=187;epage=193;aulast=Pushparani;type=0