Journal of Indian Society of Periodontology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 19  |  Issue : 2  |  Page : 150--154

Is gamma-glutamyl transpeptidase a biomarker for oxidative stress in periodontitis?


Meenakshi Sreeram1, Adinath Narayan Suryakar2, Nitin Hemchandra Dani3 
1 Department of Physiology and Biochemistry, MGV's KBH Dental College and Hospital, Nasik, Maharashtra, India
2 DY Patil University, Pune, Maharashtra, India
3 Department of Periodontology, MGV's KBH Dental College and Hospital, Nasik, Maharashtra, India

Correspondence Address:
Prof. Meenakshi Sreeram
Flat No. 1, Shiv Om Apartments, Dr. Munje Path, Samarth Nagar, Nasik - 422 005, Maharashtra
India

Context: Periodontal disease and oxidative stress (OS) are part of a vicious cycle with each causing a deleterious effect on the other causing changes in the levels of antioxidants, and enzymes of antioxidant defense. Biomarkers and methods used for measuring OS are very expensive. Aims: To see how gamma-glutamyltransferase (GGT) fares, as a biomarker for OS in periodontits along with other routinely used biomarkers. Design: A cross-sectional study involving 300 people of which 150 were cases and 150 were controls. Setting: Candidates enrolled were patients visiting the OPD of MGVSQs Dental College and Hospital, Nasik, India between January 2011 and December 2012. Materials and Methods: Serum samples of patients with periodontitis, and controls were analyzed for malondialdehyde, superoxide dismutase (SOD), glutathione peroxidase (GPx), uric acid, and GGT. Statistical Analysis Used: Analysis was performed using StudentSQs t test. P <0.05 were considered to be significant. Results: Malondialdehyde values were found to be significantly higher cases, while SOD, GPx and uric acid levels were found to be lower than controls. GGT levels were significantly higher in cases as compared to controls. Conclusions: GGT may be used as a cheap, quick, easy and precise marker for measuring OS.


How to cite this article:
Sreeram M, Suryakar AN, Dani NH. Is gamma-glutamyl transpeptidase a biomarker for oxidative stress in periodontitis?.J Indian Soc Periodontol 2015;19:150-154


How to cite this URL:
Sreeram M, Suryakar AN, Dani NH. Is gamma-glutamyl transpeptidase a biomarker for oxidative stress in periodontitis?. J Indian Soc Periodontol [serial online] 2015 [cited 2021 Sep 23 ];19:150-154
Available from: https://www.jisponline.com/article.asp?issn=0972-124X;year=2015;volume=19;issue=2;spage=150;epage=154;aulast=Sreeram;type=0