Journal of Indian Society of Periodontology

REVIEW ARTICLE
Year
: 2021  |  Volume : 25  |  Issue : 4  |  Page : 278--282

Evidence revealing the role of T cell regulators (Tregs) in periodontal diseases: A review


Paavai Ilango1, Dhanapriya Kumar1, Arulpari Mahalingam2, Abirami Thanigaimalai1, Vineela Katam Reddy3 
1 Department of Periodontics, Priyadarshini Dental College and Hospital, Thiruvallur, India
2 Department of Pedodontics, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India
3 Department of Periodontics, Indira Gandhi Dental College and Hospital, Puducherry, India

Correspondence Address:
Paavai Ilango
Priyadarshini Dental College and Hospital, No. 1. V. G. R Gardens, V. G. R. Nagar, Pandur, Thiruvallur - 631 203, Tamil Nadu
India

Periodontitis is an inflammatory disease of the periodontium, which is a reflection of the overgrowth of oral commensals. This alteration in the oral microbiota initiates inflammation of the gingiva, which when left untreated, terminates with the resorption of the alveolar bone that may lead to a poor and hopeless prognosis. With upcoming trends in modulating the host's immunity, the role of regulatory T-cells has gained importance. These T-cells defend against inflammation and autoimmunity as they suppress both. However, in both the conditions, the regulatory cells are invariably reduced in number. Novel methods to enhance the function of Tregs have made their way in dentistry, as a promising approach to cure periodontitis. This article discusses various significant tests and trials of Tregs in the recent years.


How to cite this article:
Ilango P, Kumar D, Mahalingam A, Thanigaimalai A, Reddy VK. Evidence revealing the role of T cell regulators (Tregs) in periodontal diseases: A review.J Indian Soc Periodontol 2021;25:278-282


How to cite this URL:
Ilango P, Kumar D, Mahalingam A, Thanigaimalai A, Reddy VK. Evidence revealing the role of T cell regulators (Tregs) in periodontal diseases: A review. J Indian Soc Periodontol [serial online] 2021 [cited 2021 Aug 3 ];25:278-282
Available from: https://www.jisponline.com/article.asp?issn=0972-124X;year=2021;volume=25;issue=4;spage=278;epage=282;aulast=Ilango;type=0